Antileishmanial activity of lapachol analogues
نویسندگان
چکیده
منابع مشابه
Antileishmanial activity of lapachol analogues.
The antileishmanial activity of lapachol, isolapachol, and dihydrolapachol, along with soluble derivatives (potassium salt) and acetate was obtained. All the compounds were assayed against metacyclic promastigotes of two different species of Leishmania associated to tegumentar leishmaniasis: L. amazonensis and L. braziliensis. All compounds presented significant activity, being isolapachol acet...
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Leishmania amazonensis is the etiologic agent of the cutaneous and diffuse leishmaniasis often associated with drug resistance. Lapachol [2-hydroxy-3-(3'-methyl-2-butenyl)-1,4-naphthoquinone] displays a wide range of antimicrobial properties against many pathogens. In this study, using the classic microscopic in vitro model, we have analyzed the effects of a series of lapachol and chlorides com...
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ژورنال
عنوان ژورنال: Memórias do Instituto Oswaldo Cruz
سال: 2004
ISSN: 0074-0276
DOI: 10.1590/s0074-02762004000700017